2. Signaling Pathways
  3. GPCR/G Protein
  4. Angiotensin Receptor

Angiotensin Receptor

Angiotensin Receptor

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Angiotensin receptors are a class of G protein-coupled receptors with angiotensin II as their ligands. They are important in the renin-angiotensin system: they are responsible for the signal transduction of the vasoconstricting stimulus of the main effector hormone, angiotensin II. The AT1 and AT2 receptors have a similar affinity for angiotensin II, which is their main ligand. The AT1 receptor is the best elucidated angiotensin receptor. AT2 receptors are more plentiful in the fetus and neonate. Other poorly characterized subtypes include the AT3 and AT4 receptors.

Angiotensin Receptor Isoform Specific Products:

Angiotensin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-117858
    CL-329167
    		Antagonist
    CL-329167 (compound 12) is an orally active and competitive angiotensin II receptor antagonist (IC50=6 nM). CL-329167 can be used in the research of hypertension.
    CL-329167
  • HY-W741441
    Tetrahydro Aldosterone
    		Antagonist
    Tetrahydro Aldosterone is a steroid which can inhibit adrenal angiotensin II receptors with an IC50 of 10 μM.
    Tetrahydro Aldosterone
  • HY-B0935R
    Benzyl benzoate (Standard)
    		Inhibitor
    Benzyl benzoate (Standard) is the analytical standard of Benzyl benzoate. This product is intended for research and analytical applications. Benzyl benzoate (Phenylmethyl benzoate) is an orally active anti-scabies agent, acaricide (EC50= 0.06 g/m2) and fungicide. Benzyl benzoate is an angiotensin II (Ang II) inhibitor with antihypertensive effects. Benzyl benzoate can be used in perfumes, pharmaceuticals and the food industry.
    Benzyl benzoate (Standard)
  • HY-12765R
    Losartan Carboxylic Acid (Standard)
    		Antagonist
    Losartan Carboxylic Acid (Standard) is the analytical standard of Losartan Carboxylic Acid. This product is intended for research and analytical applications. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure[4].
    Losartan Carboxylic Acid (Standard)
  • HY-14914R
    Azilsartan (Standard)
    		Antagonist
    Azilsartan (Standard) is the analytical standard of Azilsartan. This product is intended for research and analytical applications. Azilsartan (TAK-536) is an orally active, potent, selective and specific angiotensin II type 1 receptor (AT1) antagonist. Azilsartan induces ROS formation and apoptosis in HepG2 cells. Azilsartan shows neuroprotective and anticancer activity. Azilsartan can be used for hypertension and stroke research.
    Azilsartan (Standard)
  • HY-W707384
    Candesartan Cilexetil-d11
    		Antagonist
    Candesartan Cilexetil-d11 (TCV-116-d11) is deuterium labeled Candesartan Cilexetil. Candesartan Cilexetil (TCV-116) is an angiotensin II receptor inhibitor. Candesartan Cilexetil ameliorates the pulmonary fibrosis and has antiviral and skin wound healing effect. Candesartan Cilexetil can be used for the research of high blood pressure.
    Candesartan Cilexetil-d<sub>11</sub>
  • HY-19156A
    ZD-6888 hydrochloride
    		Antagonist
    ZD-6888 hydrochloride (ICI-D 6888 hydrochloride) is an antagonist for angiotensin II, which competitively inhibits the angiotensin II-mediated release of renin, affects the renal structure and function.
    ZD-6888 hydrochloride
  • HY-W414915R
    Valsartan methyl ester (Standard)
    		Antagonist
    Valsartan methyl ester (Standard) is the analytical standard of Valsartan methyl ester. This product is intended for research and analytical applications. Valsartan methyl ester (Compound 3) is a derivative of Valsartan (HY-18204). Valsartan methyl ester is an orally active antagonist for angiotensin II, that inhibits angiotensin II (IC50 of 0.06 μM), angiotensin II-induced pressor response in rabbit aorta (IC50 of 0.068 μM) and angiotensin II-induced pressor response in the pithed rat model (10% inhibition at 10 mg/kg, p.o.).
    Valsartan methyl ester (Standard)
  • HY-17512R
    Losartan (Standard)
    		Antagonist
    Losartan (Standard) is the analytical standard of Losartan. This product is intended for research and analytical applications. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.
    Losartan (Standard)
  • HY-121767
    PD 123177
    		Antagonist
    PD 123177 is a nonpeptide antagonist specific for angiotensin II (AII) subtype AT2 receptor in mammalian systems.
    PD 123177
  • HY-B1800R
    Tolonidine (Standard)
    		Inhibitor
    Tolonidine (Standard) is the analytical standard of Tolonidine. This product is intended for research and analytical applications. Tolonidine is a derivative of imidazoline. Tolonidine is orally active and has been shown to possess hypotensive and antihypertensive properties.
    Tolonidine (Standard)
  • HY-N9520
    1-Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone
    		Antagonist
    Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone9 is an antagonist of angiotensin II receptor (IC50=48.2 μM). Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone9 is a quinolone alkaloid from Evodia rutaecarpa.
    1-Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone
  • HY-117627
    L 158338
    		Antagonist
    L 158338 is an angiotensin II receptor antagonist. L 158338 alleviates acidosis and increases coronary blood flow during the ischemic period and increases coronary blood flow during the reperfusion period. L 158338 can be used to study myocardial injury during ischemia and reperfusion.
    L 158338
  • HY-B0202AS
    Irbesartan-d7 hydrochloride
    		Antagonist
    Irbesartan-d7 hydrochloride is deuterated labeled Irbesartan hydrochloride (HY-B0202A). Irbesartan (SR-47436) hydrochloride is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan hydrochloride can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan hydrochloride can be used for the research of high blood pressure, heart failure, and diabetic kidney disease.
    Irbesartan-d<sub>7</sub> hydrochloride
  • HY-W098792
    Candesartan methyl ester
    		Antagonist 99.07%
    Candesartan methyl ester is an antagonist for angiotensin II (AII) receptor with an IC50 of 0.11 μM. Candesartan methyl ester exhibits blood pressure lowering activity in rats models.
    Candesartan methyl ester
  • HY-101574
    Pratosartan
    		Antagonist
    Pratosartan is a selective angiotensin II receptor antagonist.
    Pratosartan
  • HY-19214
    Elisartan
    		Antagonist
    Elisartan is an orally active non-peptide pro-agent of angiotensin II AT1 receptor antagonist HN-12206, and shows anti-hypertension activities.
    Elisartan
  • HY-101706
    CGP48369
    		Antagonist
    CGP48369 is a nonpeptidic angiotensin II receptor antagonist, used for anti-hypertensive research.
    CGP48369
  • HY-19191
    L-159282
    		Antagonist
    L-159282 is a highly potent, orally active, nonpeptide angiotensin II receptor antagonist, with anti-hypertensive activity.
    L-159282
  • HY-101618
    L162389
    		Antagonist
    L162389 is a potent antagonist of angiotensin AT1 receptor with Ki of 28 nM.
    L162389
Cat. No. Product Name / Synonyms Application Reactivity
Angiotensin Receptor Isoform Comparison

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